Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302673 | 1.00 | TDP1 (0.35) | TDP1TSHRMAPTCACNA1BAPBA1 | |
| Hydrochloric Acid SCHEMBL8388839 | 0.98 | TDP1 (0.34) | TDP1TSHRMAPTCACNA1BAPBA1 | |
| Hydrochloric Acid SCHEMBL8388834 | 0.98 | TDP1 (0.34) | TDP1TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL18159716 | 0.82 | TDP1 (0.39) | TDP1TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL10049737 | 0.79 | TDP1 (0.45) | TDP1TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL28287911 | 0.77 | TDP1 (0.40) | TDP1TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL9313394 | 0.74 | TDP1 (0.38) | TDP1TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL11079356 | 0.74 | TDP1 (0.38) | TDP1TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL18756429 | 0.74 | MAPT (0.38) | TDP1TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL17324271 | 0.74 | GFPT1 (0.45) | MAPTCACNA1BAPBA1CASP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996039137-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |