Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296331 | 0.84 | ALDH1A1 (0.39) | KDM4EALDH1A1GAASLC6A2SLC6A3 | |
| SCHEMBL7325147 | 0.77 | ALDH1A1 (0.36) | KDM4EALDH1A1GAAACHEHPGD | |
| SCHEMBL8296894 | 0.76 | — | — | |
| SCHEMBL8297068 | 0.76 | SMN1; SMN2 (0.41) | KDM4EALDH1A1SMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL14810317 | 0.75 | HTR4 (0.48) | KDM4EALDH1A1GAAACHE | |
| SCHEMBL3944054 | 0.75 | MAPT (0.41) | KDM4EALDH1A1HSD17B10KMT2AHTT | |
| SCHEMBL21955361 | 0.74 | KDM4E (0.39) | KDM4EALDH1A1SLC6A3HPGDSMN1; SMN2 | |
| SCHEMBL8690082 | 0.72 | KDM4E (0.37) | KDM4EALDH1A1GAASLC6A2SLC6A3 | |
| SCHEMBL13315460 | 0.72 | ALDH1A1 (0.41) | KDM4EALDH1A1GAASLC6A2SLC6A3 | |
| SCHEMBL3943384 | 0.71 | MAPT (0.39) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003124-A1 | HETEROCYCLIC SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-13 | — | — | WO | disclosed |