Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8293359 | 0.91 | ADORA2B (0.40) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8339196 | 0.79 | MAPT (0.41) | HPGDHSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL8340428 | 0.79 | GAA (0.41) | PDE4APDE4BPDE4CPDE4DHSD17B10 | |
| SCHEMBL10720383 | 0.75 | GPR84 (0.49) | HPGDHSD17B10GPR84ALDH1A1 | |
| SCHEMBL10723004 | 0.75 | GPR84 (0.49) | HPGDHSD17B10GPR84ALDH1A1 | |
| SCHEMBL7274821 | 0.71 | ADORA2A (0.43) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9118456 | 0.69 | PDE4A (0.44) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL16581427 | 0.68 | ADORA2A (0.48) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8597032 | 0.67 | HRH3 (0.36) | HPGDGPR84KDM4EMEN1KMT2A | |
| SCHEMBL13199363 | 0.67 | PDE4A (0.47) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579766-B1 | N-ARYLHETEROARYLALKYL IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | SEARLE & CO (US) | 1999-06-02 | — | — | EP | disclosed |