Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CCND1 | P24385 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | MLYCD | O95822 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8863944 | 0.87 | MLYCD (0.60) | KMT2AMEN1TDP1NPC1RAB9A | |
| SCHEMBL14600381 | 0.83 | KMT2A (0.52) | KMT2AMEN1NPC1RAB9AL3MBTL1 | |
| SCHEMBL2228900 | 0.82 | HPGD (0.59) | KMT2AMEN1CDK4CCND1TDP1 | |
| SCHEMBL2228587 | 0.82 | KMT2A (0.82) | KMT2AMEN1TDP1HPGDL3MBTL1 | |
| SCHEMBL19903834 | 0.79 | HPGD (0.58) | KMT2AMEN1CDK4CCND1TDP1 | |
| SCHEMBL12163948 | 0.79 | HPGD (0.63) | KMT2AMEN1CDK4CCND1TDP1 | |
| SCHEMBL23417313 | 0.79 | HPGD (0.51) | LPAR1KMT2AMEN1CDK4CCND1 | |
| SCHEMBL18773897 | 0.78 | KMT2A (0.69) | KMT2AMEN1CDK4CCND1TDP1 | |
| SCHEMBL13166884 | 0.78 | KMT2A (0.68) | LPAR1KMT2AMEN1TDP1HPGD | |
| SCHEMBL15676740 | 0.77 | KMT2A (0.59) | KMT2AMEN1CDK4CCND1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166603-B2 | Dihydropyrimidone inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB CO. (US) | 2007-01-23 | — | — | US | disclosed |
| WO-2005009392-A2 | DIHYDROPYRIMIDONE INHIBITORS OF CALCIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-03 | — | — | WO | disclosed |