Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303262 | 1.00 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL5086406 | 0.83 | ALOX5 (0.38) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4728458 | 0.83 | ALOX5 (0.38) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8610038 | 0.81 | NPC1 (0.47) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8304850 | 0.78 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8304852 | 0.78 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8611009 | 0.77 | POLB (0.42) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8304182 | 0.76 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8304186 | 0.76 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8308678 | 0.75 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832078-B1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-10-20 | — | — | EP | disclosed |
| EP-0832078-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040659-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |