Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | STK25 | O00506 | 1/20 | 0.35 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303355 | 1.00 | DRD2 (0.49) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8299061 | 0.84 | DRD2 (0.46) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8303694 | 0.84 | DRD2 (0.46) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL9092152 | 0.78 | DRD2 (0.58) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL9092160 | 0.78 | DRD2 (0.58) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL1389027 | 0.77 | DRD4 (0.41) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL1389028 | 0.77 | DRD4 (0.41) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8429503 | 0.76 | KDM4E (0.64) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8429501 | 0.76 | KDM4E (0.64) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL1388210 | 0.75 | DRD4 (0.66) | DRD2DRD4DRD3KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | claimed |
| EP-0701555-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-03-20 | — | — | EP | claimed |
| WO-1994021626-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | claimed |
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | disclosed |
| US-5665732-A | Indazole derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1997-09-09 | — | — | US | disclosed |
| EP-0701555-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1994021626-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |