Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299061 | 1.00 | DRD2 (0.46) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8303352 | 0.84 | DRD2 (0.49) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8303355 | 0.84 | DRD2 (0.49) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8299419 | 0.78 | DRD2 (0.38) | DRD2DRD4DRD3KDM4EKMT2A | |
| SCHEMBL8299074 | 0.77 | PARP1 (0.46) | DRD2DRD4DRD3 | |
| SCHEMBL8429503 | 0.75 | KDM4E (0.64) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8429501 | 0.75 | KDM4E (0.64) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8296824 | 0.74 | CD44 (0.48) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8428835 | 0.73 | KDM4E (0.66) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8428831 | 0.73 | KDM4E (0.66) | DRD2DRD4DRD3KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | claimed |
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | disclosed |
| US-5665732-A | Indazole derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1997-09-09 | — | — | US | disclosed |
| EP-0701555-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1994021626-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |