SCHEMBL8303374

SCHEMBL8303374

N#Cc1ccc(Cc2ccc(Cl)c(Cl)c2)c(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 3/20 0.51
HTR2A P28223 2/20 0.51
SLC6A4 P31645 8/20 0.49
SLC6A3 Q01959 7/20 0.49
SLC6A2 P23975 6/20 0.49
PTGES2 Q9H7Z7 2/20 0.41
IDO1 P14902 1/20 0.40
VCAM1 P19320 1/20 0.39
SLC5A2 P31639 1/20 0.38
PNMT P11086 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
LOXL2 Q9Y4K0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL825866 0.80 VCAM1 (0.53) KCNH2HTR2ASLC6A4SLC6A3SLC6A2
SCHEMBL4030840 0.77 KCNH2 (0.58) KCNH2HTR2ASLC6A4SLC6A3SLC6A2
SCHEMBL10931372 0.76 VCAM1 (0.50) KCNH2HTR2ASLC6A4SLC6A3SLC6A2
SCHEMBL7773063 0.74 ALDH1A1 (0.43) KCNH2HTR2ASLC6A4SLC6A3VCAM1
SCHEMBL2678910 0.73 LOXL2 (0.47) KCNH2HTR2ASLC6A4SLC6A3VCAM1
SCHEMBL533946 0.73 ALDH1A1 (0.42) KCNH2HTR2ASLC6A4SLC6A3VCAM1
SCHEMBL12653174 0.73 ALDH1A1 (0.42) KCNH2HTR2ASLC6A4SLC6A3VCAM1
SCHEMBL15561990 0.73 ALDH1A1 (0.45) KCNH2HTR2ASLC6A4SLC6A3VCAM1
SCHEMBL14107962 0.73 CYP2A6 (0.47) KCNH2HTR2ASLC6A4SLC6A3VCAM1
Hydrochloric Acid SCHEMBL6490072 0.72 LOXL2 (0.45) KCNH2HTR2ASLC6A4SLC6A3IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648752-B1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-10-06 EP disclosed
US-5700824-A Triazole derivatives, insecticide, acaricide and methods thereof KUMIAI CHEMICAL INDUSTRIAL CO. LTD. (JP) 1997-12-23 US disclosed
US-5616594-A Triazole derivatives, insecticide, acaricide and methods thereof IHARA CHEMICAL INDUSTRY CO. LTD. (JP) 1997-04-01 US disclosed
EP-0648752-A1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-04-19 EP disclosed