Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346338 | 0.86 | — | — | |
| Methyl Alcohol SCHEMBL8740635 | 0.84 | CRBN (0.39) | CRBNTAS2R38KDM4E | |
| SCHEMBL15080651 | 0.77 | CRBN (0.35) | CRBNTAS2R38 | |
| Acrylamide SCHEMBL28097172 | 0.77 | ALDH1A1 (0.46) | CRBNTAS2R38ALOX15HSD17B10 | |
| Methacrylic Acid SCHEMBL3621684 | 0.76 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2KDM4EKDM6B | |
| Methacrylic Acid SCHEMBL8620266 | 0.76 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2KDM4EKDM6B | |
| SCHEMBL11304412 | 0.75 | GLRA1 (0.36) | GLRA1SLC6A9OR51E2 | |
| Glycine SCHEMBL1947837 | 0.71 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2CRBNKDM4E | |
| Glycine SCHEMBL10795794 | 0.70 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2KDM4EKDM6B | |
| Pyruvate SCHEMBL8404862 | 0.70 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2KDM4EKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581250-B1 | Process for biotechnical preparation of L-thienylalanines in enantiomere pure form from 2-hydroxy-3-thienyl-acrylic acids and their use | HOECHST AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| EP-0581250-A2 | Process for biotechnical preparation of L-thienylalanines in enantiomere pure form from 2-hydroxy-3-thienyl-acrylic acids and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-02-02 | — | — | EP | disclosed |