Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.59 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.59 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL8620266 | 1.00 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2TDP1GABRR1 | |
| Methacrylic Acid SCHEMBL18222437 | 0.91 | — | — | |
| Glycine SCHEMBL27995763 | 0.86 | TDP1 (0.67) | GLRA1SLC6A9OR51E2TDP1GABRR1 | |
| Methacrylic Acid SCHEMBL1399515 | 0.86 | TDP1 (0.50) | GLRA1SLC6A9OR51E2TDP1GABRR1 | |
| Methacrylic Acid SCHEMBL9300252 | 0.85 | TDP1 (0.47) | GLRA1SLC6A9OR51E2TDP1GABRR1 | |
| Methacrylic Acid SCHEMBL20917641 | 0.85 | TDP1 (0.47) | GLRA1SLC6A9OR51E2TDP1GABRR1 | |
| Methacrylic Acid SCHEMBL4931388 | 0.85 | — | — | |
| Methacrylic Acid SCHEMBL1399516 | 0.85 | TDP1 (0.47) | GLRA1SLC6A9OR51E2TDP1GABRR1 | |
| Methacrylic Acid SCHEMBL8678385 | 0.82 | TDP1 (0.45) | GLRA1SLC6A9OR51E2TDP1GABRR1 | |
| Methacrylic Acid SCHEMBL3989175 | 0.82 | TDP1 (0.45) | GLRA1SLC6A9OR51E2TDP1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502603-A | Degradable polymer material | 南洋理工大学 | 2022-05-13 | — | — | CN | claimed |
| US-5679776-A | Process for preparing a concentrate of blood coagulation factor VIII-von willebrand factor complex from total plasma | CENTRE REGIONAL DE TRANSFUSION SANGUINE DE LILLE (FR) | 1997-10-21 | — | — | US | claimed |
| WO-2022220019-A1 | LONG-CHAIN DNA SYNTHESIS USING NON-NATURAL BASE | 国立大学法人東京工業大学 | 2022-10-20 | — | — | WO | disclosed |
| US-11254789-B2 | Ionically modified silicones, compositions, and medical devices formed therefrom | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2022-02-22 | — | — | US | disclosed |
| CN-110431203-B | Ionically modified silicones, compositions, and medical devices formed therefrom | 莫门蒂夫性能材料股份有限公司 | 2021-11-02 | — | — | CN | disclosed |
| CN-109517118-B | High-strength degradable hydrogel and preparation method thereof | 天津大学 | 2021-04-30 | — | — | CN | disclosed |
| EP-3583176-B1 | IONICALLY MODIFIED SILICONES, COMPOSITIONS, AND MEDICAL DEVICES FORMED THEREFROM | MOMENTIVE PERFORMANCE MAT INC (US) | 2020-12-16 | — | — | EP | disclosed |
| US-20200223985-A1 | IONICALLY MODIFIED SILICONES, COMPOSITIONS, AND MEDICAL DEVICES FORMED THEREFROM | MOMENTIVE PERFORMANCE MATERIALS INC. | 2020-07-16 | — | — | US | disclosed |
| US-10066264-B2 | Method for analyzing target nucleic acid, kit, and analyzer | KABUSHIKI KAISHA DNAFORM (JP) | 2018-09-04 | — | — | US | disclosed |
| WO-2018152392-A1 | IONICALLY MODIFIED SILICONES, COMPOSITIONS, AND MEDICAL DEVICES FORMED THEREFROM | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2018-08-23 | — | — | WO | disclosed |
| EP-2891714-B1 | METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER | DNAFORM KK (JP) | 2018-07-11 | — | — | EP | disclosed |
| EP-3080191-B1 | HYDROPHILIC SILICONE COMPOSITION | MOMENTIVE PERFORMANCE MAT INC (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-3080191-A1 | HYDROPHILIC SILICONE COMPOSITION | Momentive Performance Materials Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| US-9296764-B2 | Hydrophilic silicone composition | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2016-03-29 | — | — | US | disclosed |
| EP-2891714-A1 | METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER | Kabushiki Kaisha Dnaform (JP) | 2015-07-08 | — | — | EP | disclosed |
| WO-2015088968-A1 | HYDROPHILIC SILICONE COMPOSITION | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| US-20150158889-A1 | HYDROPHILIC SILICONE COMPOSITION | MOMENTIVE PERFORMANCE MATERIALS INC. | 2015-06-11 | — | — | US | disclosed |
| US-20150152496-A1 | METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER | KABUSHIKI KAISHA DNAFORM (JP) | 2015-06-04 | — | — | US | disclosed |
| US-7851157-B1 | Oligonucleotide derivative, probe for detection of gene, and DNA chip | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-12-14 | — | — | US | disclosed |
| EP-1860115-A1 | OLIGONUCLEOTIDE DERIVATIVE, PROBE FOR DETECTION OF GENE, AND DNA CHIP | Tokyo Institute of Technology (JP) | 2007-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158889-A1 | HYDROPHILIC SILICONE COMPOSITION | CRYAB, CRYAA, CRYZ | GLRA1 285/4885SLC6A9 1629/4885OR51E2 496/4885 |
| US-11254789-B2 | Ionically modified silicones, compositions, and medical devices formed therefrom | ORMDL3, THEM6, ITK | GLRA1 2074/4885SLC6A9 1339/4885OR51E2 189/4885 |
| US-20200223985-A1 | IONICALLY MODIFIED SILICONES, COMPOSITIONS, AND MEDICAL DEVICES FORMED THEREFROM | ORMDL3, THEM6, ITK | GLRA1 2074/4885SLC6A9 1339/4885OR51E2 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.