Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305943 | 0.88 | HDAC8 (0.37) | KMT2AHSD17B10MEN1POLBPDE4A | |
| SCHEMBL8302569 | 0.73 | MAPT (0.42) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL8303647 | 0.69 | HDAC8 (0.45) | KMT2AHSD17B10MEN1USP2ALDH1A1 | |
| SCHEMBL9414691 | 0.69 | HDAC8 (0.38) | KMT2AHSD17B10MEN1POLBALDH1A1 | |
| SCHEMBL8304894 | 0.69 | HDAC8 (0.40) | — | |
| Hydrochloric Acid SCHEMBL8718128 | 0.68 | HDAC8 (0.37) | KMT2AHSD17B10MEN1POLBALDH1A1 | |
| SCHEMBL8715200 | 0.68 | PDE4A (0.48) | KMT2AMEN1POLBPDE4APDE4B | |
| SCHEMBL8302610 | 0.68 | LMNA (0.46) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9414967 | 0.67 | HDAC8 (0.45) | KMT2AHSD17B10MEN1POLBUSP2 | |
| Hydrochloric Acid SCHEMBL8719903 | 0.67 | HDAC8 (0.45) | KMT2AHSD17B10MEN1POLBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579059-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |