Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.33 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20738498 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2CYP1A2TDP1KDM4EPIK3CD | |
| SCHEMBL20804513 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP1A2TDP1KDM4EPIK3CD | |
| SCHEMBL24636867 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP1A2TDP1KDM4EPIK3CD | |
| SCHEMBL3572705 | 0.77 | CRHBP (0.33) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30327233 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP1A2TDP1KDM4EPIK3CD | |
| SCHEMBL25107356 | 0.76 | ALDH1A1 (0.57) | SMN1; SMN2KDM4ECHRNB2CHRNA3CHRNA4 | |
| SCHEMBL14818671 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP1A2TDP1KDM4EPIK3CD | |
| SCHEMBL19787036 | 0.75 | ALDH1A1 (0.35) | SMN1; SMN2KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL25107224 | 0.75 | CHRNB2 (0.39) | KDM4ECHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL30782079 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP1A2TDP1KDM4EPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212296-A1 | ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. SHAW RESEARCH, LLC (US) | 2022-10-06 | — | — | WO | disclosed |
| EP-3915991-A1 | PYRROLOPYRIMIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT | Voronoi Co., Ltd. (KR) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020149723-A1 | PYRROLOPYRIMIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT | 주식회사 보로노이 | 2020-07-23 | — | — | WO | disclosed |
| EP-0607374-B1 | NOVEL CYCLIC LIPID DERIVATIVES AS POTENT PAF ANTAGONISTS | PO HANG IRON & STEEL (KR) | 1999-04-07 | — | — | EP | disclosed |
| US-5700817-A | Cyclic lipid derivatives as potent PAF antagonists | POHANG IRON & STEEL CO., LTD. (KR) | 1997-12-23 | — | — | US | disclosed |
| US-5610310-A | Cyclic lipid derivatives as potent PAF antagonists | POHANG IRON & STEEL CO., LTD (KR) | 1997-03-11 | — | — | US | disclosed |
| EP-0607374-A1 | NOVEL CYCLIC LIPID DERIVATIVES AS POTENT PAF ANTAGONISTS | POHANG IRON & STEEL CO., LTD. (KR) | 1994-07-27 | — | — | EP | disclosed |
| WO-1994000447-A1 | NOVEL CYCLIC LIPID DERIVATIVES AS POTENT PAF ANTAGONISTS | POHANG IRON & STEEL CO., LTD. (KR) | 1994-01-06 | — | — | WO | disclosed |