Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20594028 | 0.82 | L3MBTL1 (0.54) | L3MBTL1MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL15415598 | 0.79 | ALDH1A1 (0.42) | L3MBTL1MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL8507598 | 0.79 | MAPT (0.51) | L3MBTL1MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL8303530 | 0.78 | MAPT (0.54) | L3MBTL1MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL8741872 | 0.74 | MAPT (0.60) | L3MBTL1MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL6906184 | 0.74 | MAPT (0.44) | L3MBTL1MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL11598616 | 0.74 | ALDH1A1 (0.47) | L3MBTL1MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL27603978 | 0.72 | CHRM2 (0.69) | L3MBTL1MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL10731279 | 0.72 | ALDH1A1 (0.58) | L3MBTL1MAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL74371 | 0.72 | ALDH1A1 (0.58) | L3MBTL1MAPK1ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996039137-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |