Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507598 | 0.98 | MAPT (0.51) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL20589146 | 0.83 | DPP7 (0.41) | MAPTL3MBTL1MAPK1NPSR1KMT2A | |
| SCHEMBL20594028 | 0.78 | L3MBTL1 (0.54) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL8303682 | 0.78 | L3MBTL1 (0.54) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL31502846 | 0.76 | MAPT (0.52) | MAPTL3MBTL1MAPK1NPSR1 | |
| SCHEMBL10948705 | 0.75 | MAPT (0.44) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL8741872 | 0.74 | MAPT (0.60) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL20589054 | 0.73 | ALDH1A1 (0.43) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL6737298 | 0.73 | ALDH1A1 (0.43) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL3969170 | 0.72 | DPP7 (0.48) | MAPTMAPK1NPSR1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931079-A1 | SUBSTITUTED BENZOCYCLOHEPTAPYRIDINE DERIVATIVES USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998011099-A1 | SUBSTITUTED BENZOCYCLOHEPTAPYRIDINE DERIVATIVES USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-03-19 | — | — | WO | disclosed |