Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760169 | 0.80 | HTR2A (0.52) | HTR2ADRD4 | |
| SCHEMBL8306648 | 0.69 | DRD4 (0.54) | HTR2ADRD4 | |
| Fumaric Acid SCHEMBL9298029 | 0.69 | DRD4 (0.60) | HTR2ADRD4 | |
| Maleic Acid SCHEMBL7993402 | 0.69 | DRD4 (0.60) | HTR2ADRD4 | |
| SCHEMBL8307680 | 0.69 | HTR2A (0.65) | HTR2ADRD4HTR2C | |
| SCHEMBL8303565 | 0.68 | CYP2D6 (0.34) | HTR2ACYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7993630 | 0.68 | HTR1A (0.58) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7979099 | 0.67 | HTR1A (0.57) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8302001 | 0.61 | PARP1 (0.48) | — | |
| SCHEMBL9411187 | 0.60 | HTR2A (0.64) | HTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458234-B1 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0458234-A2 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5041445-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-20 | — | — | US | disclosed |