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SCHEMBL8303747

SCHEMBL8303747

CC(=O)CCC(=O)OCC(=O)N1CCN(c2ccc(N3CC(CNC(C)=O)OC3=O)cc2F)CC1

nearest known ligand 0.66

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 6/20 0.66
▸ MAOB P27338 6/20 0.66
▸ PTGS1 P23219 2/20 0.66
▸ SDHA P31040 2/20 0.66
▸ LMNA P02545 1/20 0.66
▸ CALML3 P27482 1/20 0.66
▸ F10 P00742 6/20 0.58
▸ TOP2B Q02880 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8307467 0.92 MAOB (0.66) MAOAMAOBPTGS1SDHALMNA
SCHEMBL7488174 0.91 MAOB (0.74) MAOAMAOBPTGS1SDHALMNA
SCHEMBL8307137 0.90 MAOA (0.62) MAOAMAOBPTGS1SDHALMNA
SCHEMBL8304945 0.90 MAOB (0.70) MAOAMAOBPTGS1SDHALMNA
SCHEMBL8307496 0.90 MAOA (0.51) MAOAMAOBPTGS1SDHALMNA
SCHEMBL12674054 0.88 MAOB (0.73) MAOAMAOBPTGS1SDHALMNA
SCHEMBL13694074 0.88 MAOB (0.73) MAOAMAOBPTGS1SDHALMNA
Eperezolid SCHEMBL1176950 0.87 MAOB (0.76) MAOAMAOBPTGS1SDHALMNA
Eperezolid SCHEMBL186562 0.87 MAOB (0.76) MAOAMAOBPTGS1SDHALMNA
Eperezolid SCHEMBL29421647 0.87 MAOB (0.76) MAOAMAOBPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0730591-B1 ESTERS OF SUBSTITUTED-HYDROXYACETYL PIPERAZINE PHENYL OXAZOLIDINONES UPJOHN CO (US) 1999-07-14 — — EP claimed