Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303799 | 1.00 | EPHX1 (0.42) | EPHX1CTSKACHEALDH1A1SMN1; SMN2 | |
| SCHEMBL5605365 | 0.91 | GPR84 (0.47) | EPHX1ACHEGPR84 | |
| SCHEMBL19145239 | 0.87 | EPHX1 (0.42) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8322165 | 0.83 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19837622 | 0.82 | EPHX1 (0.38) | EPHX1CTSKACHEALDH1A1SMN1; SMN2 | |
| SCHEMBL8321483 | 0.81 | EPHX1 (0.41) | EPHX1CTSKACHE | |
| SCHEMBL282155 | 0.80 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5959811 | 0.80 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1840802 | 0.80 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7404539 | 0.79 | ACHE (0.46) | EPHX1ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972984-A | LOW MOLECULAR WEIGHT PEPTIDYL COMPOUNDS THAT DO NOT HAVE A THIOL MOIETY. | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5756528-A | ANTICARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996039137-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |