Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2344663 | 0.85 | EPHX1 (0.43) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5622460 | 0.84 | EPHX1 (0.48) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5959811 | 0.83 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL282155 | 0.83 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11072059 | 0.82 | EPHX1 (0.47) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6984629 | 0.82 | EPHX1 (0.47) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7404539 | 0.81 | ACHE (0.46) | EPHX1ACHEALDH1A1 | |
| SCHEMBL8764308 | 0.81 | EPHX1 (0.43) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8303799 | 0.80 | EPHX1 (0.42) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4592660 | 0.80 | EPHX1 (0.42) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861604-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2015-04-22 | — | — | EP | disclosed |
| EP-2859009-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013185090-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2013-12-12 | — | — | WO | disclosed |
| WO-2013185103-A1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2013-12-12 | — | — | WO | disclosed |
| EP-2321272-A1 | ORGANIC COMPOUNDS | Nabriva Therapeutics AG (AT) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010025482-A1 | ORGANIC COMPOUNDS | NABRIVA THERAPEUTICS AG (AT) | 2010-03-11 | — | — | WO | disclosed |