Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845697 | 0.82 | LTA4H (0.47) | CHRNB4CHRNA3ALK | |
| SCHEMBL6979570 | 0.82 | LTA4H (0.47) | CHRNB4CHRNA3ALK | |
| SCHEMBL4322026 | 0.77 | LTA4H (0.56) | ALK | |
| Hydrochloric Acid SCHEMBL21522191 | 0.76 | CYSLTR1 (0.45) | CHRNB4CHRNA3ALKLMNAMAPK1 | |
| SCHEMBL25155912 | 0.76 | ALK (0.45) | CHRNB4CHRNA3ALKHTTSMN1; SMN2 | |
| SCHEMBL8439888 | 0.75 | CHRNB2 (0.63) | CHRNB4CHRNA3CHRNB2CHRNA4CYP2D6 | |
| SCHEMBL8439884 | 0.75 | CHRNB2 (0.63) | CHRNB4CHRNA3CHRNB2CHRNA4CYP2D6 | |
| SCHEMBL8439886 | 0.75 | CHRNB2 (0.63) | CHRNB4CHRNA3CHRNB2CHRNA4CYP2D6 | |
| SCHEMBL8303957 | 0.74 | CHRNA3 (0.70) | CHRNB4CHRNA3 | |
| SCHEMBL2202363 | 0.74 | SSTR4 (0.40) | CHRNB4CHRNA3ALKHTTSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |