Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303889 | 1.00 | NPC1 (0.54) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8308036 | 0.85 | NPC1 (0.54) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8305637 | 0.85 | NPC1 (0.54) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8305639 | 0.85 | NPC1 (0.54) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8549505 | 0.85 | RAB9A (0.67) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1298504 | 0.81 | NPC1 (0.70) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14352146 | 0.81 | NPC1 (0.70) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8550398 | 0.80 | NPC1 (0.58) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3611789 | 0.79 | TAAR1 (0.70) | TAAR1MAOB | |
| SCHEMBL3611792 | 0.79 | TAAR1 (0.70) | TAAR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832078-B1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-10-20 | — | — | EP | disclosed |
| US-5814648-A | N-hydroxyureas as antiinflammatory agents | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0832078-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040659-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |