SCHEMBL8304314

SCHEMBL8304314

Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(Cl)c(Oc2ccc(C(F)(F)F)cn2)c1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.48
L3MBTL1 Q9Y468 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TSHR P16473 1/20 0.39
HPGD P15428 1/20 0.38
KDM4E B2RXH2 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
MAPK1 P28482 1/20 0.37
POLB P06746 2/20 0.36
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
IDO1 P14902 1/20 0.35
THRB P10828 1/20 0.35
SCN9A Q15858 3/20 0.35
PTGES O14684 2/20 0.35
LIPE Q05469 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8300520 0.96 KMT2A (0.47) KMT2AL3MBTL1SMN1; SMN2TSHRHPGD
SCHEMBL8300716 0.94 KMT2A (0.45) KMT2AL3MBTL1SMN1; SMN2TSHRHPGD
SCHEMBL8303158 0.93 KMT2A (0.48) KMT2AL3MBTL1SMN1; SMN2TSHRHPGD
SCHEMBL8304023 0.92 KMT2A (0.44) KMT2AL3MBTL1SMN1; SMN2TSHRHPGD
SCHEMBL8298899 0.89 KMT2A (0.47) KMT2AL3MBTL1SMN1; SMN2TSHRHPGD
SCHEMBL8303496 0.86 TSHR (0.47) KMT2AL3MBTL1SMN1; SMN2TSHRHPGD
SCHEMBL8304674 0.84 GABRA5 (0.38) KMT2AL3MBTL1KDM4ENPSR1MAPK1
SCHEMBL8942500 0.83 MRGPRX4 (0.41) KMT2AKDM4ENPSR1POLBMEN1
SCHEMBL8299568 0.82 THRB (0.44) KMT2AMAPK1LMNAIDO1THRB
SCHEMBL8303629 0.82 HPGD (0.46) KMT2AL3MBTL1HPGDKDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648752-B1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-10-06 EP disclosed
US-5700824-A Triazole derivatives, insecticide, acaricide and methods thereof KUMIAI CHEMICAL INDUSTRIAL CO. LTD. (JP) 1997-12-23 US disclosed
US-5616594-A Triazole derivatives, insecticide, acaricide and methods thereof IHARA CHEMICAL INDUSTRY CO. LTD. (JP) 1997-04-01 US disclosed
US-5597915-A ANTAGONISTS OF CHOLECYSTOKININ AND GASTRIN RECEPTORS MERCK SHARP & DOHME LTD. (GB) 1997-01-28 US disclosed
EP-0648752-A1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-04-19 EP disclosed