Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.57 |
| ▸ | FABP4 | P15090 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KLK1 | P06870 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17503889 | 0.91 | NOTUM (0.83) | NOTUMKMT2AMEN1TSHRS1PR2 | |
| SCHEMBL17503896 | 0.88 | NOTUM (0.78) | NOTUMKMT2AMEN1TSHRS1PR2 | |
| SCHEMBL15998970 | 0.88 | NOTUM (0.78) | NOTUMKMT2AMEN1TSHRS1PR2 | |
| SCHEMBL15998965 | 0.87 | NOTUM (0.77) | NOTUMKMT2AMEN1TSHRS1PR2 | |
| SCHEMBL14886445 | 0.87 | NOTUM (0.77) | NOTUMKMT2AMEN1TSHRS1PR2 | |
| SCHEMBL17503905 | 0.87 | NOTUM (0.75) | NOTUMKMT2AMEN1TSHRS1PR2 | |
| SCHEMBL25062489 | 0.86 | NOTUM (0.75) | NOTUMKMT2AMEN1TSHRS1PR2 | |
| SCHEMBL21332768 | 0.86 | ALDH1A1 (0.77) | NOTUMKMT2AMEN1TSHRS1PR2 | |
| SCHEMBL17503939 | 0.86 | NOTUM (0.75) | NOTUMKMT2AMEN1TSHRKLKB1 | |
| SCHEMBL3345961 | 0.86 | MEN1 (1.00) | NOTUMKMT2AMEN1TSHRS1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266840-B2 | Bicyclic heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2016-02-23 | — | — | US | disclosed |
| US-9266840-B2 | Bicyclic heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2016-02-23 | — | — | US | disclosed |
| US-20140249151-A1 | BICYCLIC HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-09-04 | — | — | US | disclosed |
| US-20140249151-A1 | BICYCLIC HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-09-04 | — | — | US | disclosed |
| WO-2013058258-A1 | BICYCLIC HETEROCYCLIC COMPOUND | アステラス製薬株式会社 (JP) | 2013-04-25 | — | — | WO | disclosed |
| CN-1058490-C | Tetrazolinone derivatives | BAYER AGROCHEM KK (JP) | 2000-11-15 | — | — | CN | disclosed |
| EP-0695748-B1 | Tetrazolinone herbicides | BAYER AGROCHEM KK (JP) | 1999-05-06 | — | — | EP | disclosed |
| US-5589439-A | HERBICIDES | NIHON BAYER AGROCHEM K.K. (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0695748-A1 | Tetrazolinone herbicides | NIHON BAYER AGROCHEM K.K. (JP) | 1996-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249151-A1 | BICYCLIC HETEROCYCLIC COMPOUND | HSD11B1, HSD17B11, HSD17B1 | NOTUM 585/4885KMT2A 3204/4885MEN1 3581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.