Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.41 |
| ▸ | FADS1 | O60427 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502392 | 0.78 | MAPK10 (0.52) | ADRA2ATRPA1ACHEMAPK10MAPK8 | |
| SCHEMBL8953013 | 0.73 | KDM4E (0.42) | ADRA2ATRPA1ACHEMAPK10MAPK8 | |
| SCHEMBL11700794 | 0.69 | KDM4E (0.57) | ADRA2ATRPA1MAPK10FADS1KDM4E | |
| SCHEMBL11756891 | 0.69 | TRPA1 (0.54) | ADRA2ATRPA1ACHEMAPK10FADS1 | |
| SCHEMBL15392392 | 0.69 | TRPA1 (0.54) | ADRA2ATRPA1ACHEMAPK10MAPK8 | |
| SCHEMBL7452500 | 0.69 | TRPA1 (0.54) | ADRA2ATRPA1ACHEMAPK10MAPK8 | |
| SCHEMBL31032755 | 0.69 | TRPA1 (0.54) | ADRA2ATRPA1ACHEMAPK10FADS1 | |
| SCHEMBL7172053 | 0.69 | TRPA1 (0.54) | ADRA2ATRPA1MAPK10FADS1KDM4E | |
| SCHEMBL11784173 | 0.68 | TSHR (0.48) | ACHEGAACYP3A4ALDH1A1HPGD | |
| SCHEMBL6583705 | 0.68 | POLB (0.37) | KDM4EAURKAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1244864-A | 2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists | PROCTER & GAMBLE (US) | 2000-02-16 | — | — | CN | disclosed |
| CN-1244864-A | 2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists | PROCTER & GAMBLE (US) | 2000-02-16 | — | — | CN | disclosed |
| EP-0944620-A1 | 2-IMIDAZOLINYLAMINOINDAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023609-A1 | 2-IMIDAZOLINYLAMINOINDAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |
| US-4036976-A | ANTIHYPERTENSIVE AGENTS | SANDOZ, INC. (US) | 1977-07-19 | — | — | US | disclosed |