Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | VNN1 | O95497 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7194395 | 0.84 | HSD17B10 (0.58) | MAPK14MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL11710988 | 0.81 | ALOX15 (0.52) | MAPK14MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL6651723 | 0.79 | GSK3B (0.53) | MAPK14GSK3BVNN1CLK1DYRK1A | |
| SCHEMBL5963546 | 0.79 | MAPK13 (0.58) | MAPK14MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2199593 | 0.77 | CYP3A4 (0.44) | MAPK14SMN1; SMN2HSD17B10MAPK13MAPK12 | |
| SCHEMBL6772685 | 0.76 | MAPK14 (0.48) | MAPK14GSK3BVNN1CLK1DYRK1A | |
| SCHEMBL5226711 | 0.75 | MAPK14 (0.50) | MAPK14GSK3BVNN1MAPTCLK1 | |
| SCHEMBL7183309 | 0.75 | SRD5A2 (0.54) | MAPK14MEN1MAPTKMT2ASMN1; SMN2 | |
| Chlorobenzene SCHEMBL27529703 | 0.75 | MAPK14 (0.55) | MAPK14MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL7090488 | 0.75 | JAK2 (0.53) | MEN1MAPTKMT2ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |