Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 4/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | TYMP | P19971 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842828 | 0.88 | BRS3 (0.54) | BRS3HRH3SAE1UBA2TYMP | |
| SCHEMBL7505077 | 0.82 | LOXL2 (0.49) | BRS3HRH3SAE1UBA2TYMP | |
| SCHEMBL7129739 | 0.82 | BRS3 (0.52) | BRS3HRH3SAE1UBA2TYMP | |
| SCHEMBL7843395 | 0.81 | HRH3 (0.47) | BRS3HRH3TYMPDAOIDO1 | |
| Hydrochloric Acid SCHEMBL8368581 | 0.81 | BRS3 (0.52) | BRS3HRH3SAE1UBA2MMP12 | |
| SCHEMBL8498703 | 0.79 | BRS3 (0.49) | BRS3HRH3SAE1UBA2TYMP | |
| SCHEMBL10588302 | 0.79 | BRS3 (0.49) | BRS3HRH3SAE1UBA2TYMP | |
| SCHEMBL7468902 | 0.79 | HRH3 (0.48) | BRS3HRH3SAE1UBA2TYMP | |
| SCHEMBL7468183 | 0.79 | BRS3 (0.47) | BRS3HRH3SAE1UBA2TYMP | |
| SCHEMBL8121737 | 0.78 | BRS3 (0.49) | BRS3HRH3SAE1UBA2TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904076-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0891339-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036585-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| WO-1997036881-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |