Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | BACE1 | P56817 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308161 | 0.90 | LMNA (0.68) | LMNAALDH1A1BACE1HTTKDM4E | |
| SCHEMBL8311830 | 0.90 | MAPT (0.68) | LMNAALDH1A1BACE1HTTKDM4E | |
| SCHEMBL8306952 | 0.88 | KDM4E (0.62) | LMNAALDH1A1BACE1HTTKDM4E | |
| SCHEMBL8307086 | 0.87 | MAPT (0.71) | LMNAALDH1A1BACE1HTTRXFP1 | |
| SCHEMBL8303972 | 0.85 | BACE1 (0.64) | LMNAALDH1A1BACE1HTTKDM4E | |
| SCHEMBL8304348 | 0.84 | BACE1 (0.68) | LMNAALDH1A1BACE1HTTKDM4E | |
| SCHEMBL8307119 | 0.84 | MAPT (0.59) | LMNAALDH1A1BACE1HTTRXFP1 | |
| SCHEMBL8304644 | 0.83 | LMNA (0.66) | LMNAALDH1A1BACE1HTTKDM4E | |
| SCHEMBL8305790 | 0.82 | MAPT (0.76) | ALDH1A1BACE1HTTKDM4ERXFP1 | |
| SCHEMBL8304646 | 0.81 | KDM4E (0.76) | ALDH1A1BACE1HTTKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078731-A1 | QUINOLINE-CARBOXYLIC ACIDS AND THE DERIVATIVES THEREOF, A FOCUSED LIBRARY | 'CHEMICAL DIVERSITY RESEARCH INSTITUTE', LTD. (RU) | 2004-09-16 | — | — | WO | disclosed |