SCHEMBL83057

SCHEMBL83057

CCOC(=O)CC(=O)O.[KH]

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.70
MGAM O43451 1/20 0.70
SI P14410 1/20 0.70
MGAM2 Q2M2H8 1/20 0.70
ALDH1A1 P00352 6/20 0.50
TRPA1 O75762 1/20 0.50
EGLN1 Q9GZT9 1/20 0.45
LMNA P02545 1/20 0.43
HSD17B10 Q99714 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ALOX15 P16050 2/20 0.42
SOAT1 P35610 1/20 0.42
LDHA P00338 1/20 0.40
SRR Q9GZT4 1/20 0.40
HCAR2 Q8TDS4 1/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29048821 1.00 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL15376 0.97
SCHEMBL30741390 0.97 GAA (0.74) GAAMGAMSIMGAM2ALDH1A1
Hydrochloric Acid SCHEMBL7634629 0.95 GAA (0.64) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL13278763 0.95 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL1068040 0.95 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
Water SCHEMBL2811574 0.95 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
Hydrochloric Acid SCHEMBL356491 0.95 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL3201235 0.95 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL3196229 0.95 GAA (0.70) GAAMGAMSIMGAM2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 268 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117624133-A Dihydroquinoline derivative and application thereof in lung cancer treatment 重庆三峡医药高等专科学校 2024-03-01 CN claimed
CN-114315746-A 3, 6-bis (dinitromethyl) -1,2,4, 5-tetrazine and synthetic method thereof 南京理工大学 2022-04-12 CN claimed
CN-1092191-C Manufacture of cyclocarbonates HOFFMANN LA ROCHE (CH) 2002-10-09 CN claimed
CN-1180703-A Manufacture of cyclocarbonates HOFFMANN LA ROCHE (CH) 1998-05-06 CN claimed
US-12508239-B2 Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures H. LUNDBECK A/S (DK) 2025-12-30 US disclosed
EP-4007571-B1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS FOR USE IN EPILEPSY OR SEIZURES H LUNDBECK AS (DK) 2025-06-18 EP disclosed
EP-4241843-B1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H LUNDBECK AS (DK) 2025-05-21 EP disclosed
US-12258305-B2 Alcohol derivatives as Kv7 potassium channel openers H. LUNDBECK A/S (DK) 2025-03-25 US disclosed
US-12227507-B2 Pharmaceutical compounds PFIZER INC. (US) 2025-02-18 US disclosed
EP-4461725-A2 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. Lundbeck A/S (DK) 2024-11-13 EP disclosed
US-20240327336-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H. LUNDBECK A/S (DK) 2024-10-03 US disclosed
EP-4007634-B1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS H LUNDBECK AS (DK) 2024-10-02 EP disclosed
US-5922717-A ANTICOAGULANTS DR. KARL THOMAE GMBH (DE) 1999-07-13 US disclosed
CN-1215401-A 4-(benzo-1,3-dioxolyl)-pyrrolidine-3-carboxylic acid derivatives endothelin antagonists ABBOTT LAB (US) 1999-04-28 CN disclosed
EP-0720981-B1 Cyclohexyloxycarbonylacetohydrazides and method for producing 1H-1,2,4-triazoles using the hydrazides FUJI PHOTO FILM CO LTD (JP) 1998-10-14 EP disclosed
WO-1998023608-A1 NOVEL INTEGRIN RECEPTOR ANTAGONISTS DUPONT PHARMACEUTICALS COMPANY (US) 1998-06-04 WO disclosed
EP-0720981-A1 Cyclohexyloxycarbonylacetohydrazides and method for producing 1H-1,2,4-triazoles using the hydrazides FUJI PHOTO FILM CO., LTD. (JP) 1996-07-10 EP disclosed
EP-0703233-A2 Process for the preparation of 5-substituted-1-azabicyclo (3.3.0) octanes SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1996-03-27 EP disclosed
US-5484940-A ULTRAVIOLET RADIATION ABSORBERS FOR PLASTICS, AMYLOID PEPTIDE INHIBITORS, ALZHEIMER*S DISEASE ATHENA NEUROSCIENCES, INC. 1996-01-16 US disclosed
CN-1105984-A Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses SANKYO CO (JP) 1995-08-02 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12227507-B2 Pharmaceutical compounds CHRNA6, GABRA6, CHRNA7 GAA 4055/4885MGAM 4718/4885SI 4030/4885
US-20240327336-A1 ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS KCNA7, KCNK17, KCNQ1 GAA 3300/4885MGAM 4161/4885SI 3619/4885
US-12508239-B2 Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures KCNN3, KCNN1, KCNN2 GAA 1921/4885MGAM 4114/4885SI 2636/4885
US-12258305-B2 Alcohol derivatives as Kv7 potassium channel openers KCNA7, KCNK17, KCNQ1 GAA 3300/4885MGAM 4161/4885SI 3619/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.