SCHEMBL8306103

SCHEMBL8306103

Fc1cc(F)cc(NN2CCOCC2)c1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.58
ALDH1A1 P00352 3/20 0.58
LMNA P02545 2/20 0.58
RAB9A P51151 2/20 0.58
MEN1 O00255 3/20 0.41
GAA P10253 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.38
EPHX2 P34913 1/20 0.36
AKT1 P31749 1/20 0.36
CNR2 P34972 1/20 0.36
LRRK2 Q5S007 1/20 0.35
MAPT P10636 2/20 0.35
ATM Q13315 1/20 0.35
TSHR P16473 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ACLY P53396 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2406119 0.82 KMT2A (0.49) KMT2AALDH1A1LMNARAB9AMEN1
SCHEMBL7125472 0.81 KMT2A (0.39) KMT2AALDH1A1LMNARAB9AMEN1
SCHEMBL7127198 0.79 KMT2A (0.38) KMT2AALDH1A1LMNARAB9AMEN1
SCHEMBL7118892 0.76 ALDH1A1 (0.36) KMT2AALDH1A1LMNARAB9ACYP2D6
SCHEMBL28436223 0.76 LMNA (0.47) KMT2AALDH1A1LMNARAB9ASMN1; SMN2
SCHEMBL7131198 0.73 KMT2A (0.37) KMT2AALDH1A1LMNARAB9AMEN1
SCHEMBL27262053 0.72 LMNA (0.64) KMT2AALDH1A1LMNARAB9AMEN1
SCHEMBL657883 0.71 MAPT (0.50) KMT2AALDH1A1LMNARAB9AMEN1
Bromide SCHEMBL7858764 0.69 MAPT (0.49) KMT2AALDH1A1LMNARAB9AMEN1
SCHEMBL12495214 0.69 LMNA (0.52) KMT2AALDH1A1LMNARAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0717738-B1 SUBSTITUTED OXAZINE AND THIAZINE OXAZOLIDINONE ANTIMICROBIALS UPJOHN CO (US) 1999-10-20 EP disclosed
US-5880118-A Substituted oxazine and thiazine oxazolidinone antimicrobials PHARMACIA & UPJOHN COMPANY (US) 1999-03-09 US disclosed
US-5688792-A BACTERICIDES PHARMACIA & UPJOHN COMPANY (US) 1997-11-18 US disclosed
EP-0717738-A1 SUBSTITUTED OXAZINE AND THIAZINE OXAZOLIDINONE ANTIMICROBIALS PHARMACIA & UPJOHN COMPANY (US) 1996-06-26 EP disclosed
WO-1995007271-A1 SUBSTITUTED OXAZINE AND THIAZINE OXAZOLIDINONE ANTIMICROBIALS THE UPJOHN COMPANY (US) 1995-03-16 WO disclosed