Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301480 | 0.83 | LMNA (0.43) | S1PR2S1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL20628680 | 0.79 | KCNH2 (0.44) | IGF1RALOX15KCNH2PPARAPPARG | |
| SCHEMBL11959919 | 0.77 | KCNH2 (0.49) | IGF1RALOX15KCNH2PPARAHDAC3 | |
| SCHEMBL27564195 | 0.77 | IGF1R (0.52) | IGF1RALOX15KCNH2PPARAHDAC3 | |
| SCHEMBL6905786 | 0.76 | KCNH2 (0.56) | IGF1RALOX15KCNH2HDAC3HDAC4 | |
| SCHEMBL28966782 | 0.75 | IGF1R (0.61) | IGF1RALOX15KCNH2HDAC3HDAC4 | |
| SCHEMBL1115439 | 0.75 | IGF1R (0.61) | IGF1RALOX15KCNH2HDAC3HDAC4 | |
| SCHEMBL9760951 | 0.75 | IDO1 (0.52) | — | |
| SCHEMBL11959867 | 0.74 | IGF1R (0.48) | IGF1RALOX15KCNH2HDAC3HDAC4 | |
| SCHEMBL20079980 | 0.74 | IDO1 (0.48) | PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915843-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSES | SMITHKLINE BEECHAM PLC (GB) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997041098-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | disclosed |