Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28139688 | 0.81 | NOTUM (0.44) | GABRA5PTGS2HSP90AA1L3MBTL1TDP1 | |
| SCHEMBL23366325 | 0.81 | PTGS2 (0.47) | GABRA5PTGS2HSP90AA1L3MBTL1TDP1 | |
| SCHEMBL3213310 | 0.81 | PTGS2 (0.41) | GABRA5PTGS2HSP90AA1L3MBTL1TDP1 | |
| SCHEMBL2929388 | 0.81 | NOTUM (0.49) | GABRA5PTGS2HSP90AA1L3MBTL1TDP1 | |
| SCHEMBL5775916 | 0.78 | NOTUM (0.46) | GABRA5PTGS2HSP90AA1L3MBTL1TDP1 | |
| SCHEMBL5772931 | 0.78 | PTGS2 (0.42) | GABRA5PTGS2HSP90AA1L3MBTL1TDP1 | |
| SCHEMBL4973045 | 0.77 | PTGS2 (0.41) | GABRA5PTGS2HSP90AA1L3MBTL1TDP1 | |
| SCHEMBL27819710 | 0.77 | KDM4E (0.49) | GABRA5PTGS2HSP90AA1TDP1LMNA | |
| SCHEMBL8168464 | 0.75 | CYP19A1 (0.44) | GABRA5PTGS2HSP90AA1PTGS1ALDH1A1 | |
| SCHEMBL11848234 | 0.74 | PTGS2 (0.39) | GABRA5PTGS2HSP90AA1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891339-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036881-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |