Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | HTR2A | P28223 | 7/20 | 0.52 |
| ▸ | HTR7 | P34969 | 7/20 | 0.52 |
| ▸ | HTR6 | P50406 | 7/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306860 | 0.78 | HTR1A (0.62) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL14359185 | 0.74 | HTR1A (0.69) | HTR1ASLC6A4HTR2AHTR7 | |
| SCHEMBL11197744 | 0.73 | DRD2 (0.59) | HTR1ASLC6A4DRD2HTR2AHTR6 | |
| SCHEMBL14358943 | 0.73 | HTR2A (0.67) | DRD2HTR2AHTR7HTR6 | |
| SCHEMBL9210499 | 0.73 | HTR1A (0.59) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL14359468 | 0.73 | HTR2A (0.72) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9213471 | 0.73 | HTR1A (0.61) | HTR1ASLC6A2SLC6A4SLC6A3HTR2A | |
| Bromide SCHEMBL10894418 | 0.73 | DRD2 (0.58) | HTR1ASLC6A4DRD2HTR2AHTR6 | |
| SCHEMBL9214106 | 0.73 | HTR1A (0.61) | HTR1ASLC6A2SLC6A4SLC6A3HTR2A | |
| Hydrochloric Acid SCHEMBL8912233 | 0.72 | HTR1A (0.47) | HTR1ASLC6A2SLC6A4SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747379-B1 | Derivatives of indole, indazole and benzisoxazole for the treatment of schizophrenia | ADIR (FR) | 1999-08-11 | — | — | EP | disclosed |
| EP-0747379-A1 | Derivatives of indole, indazole and benzisoxazole for the treatment of schizophrenia | ADIR ET COMPAGNIE (FR) | 1996-12-11 | — | — | EP | disclosed |