Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | PRKCI | P41743 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439568 | 0.89 | POLB (0.45) | ALDH1A1POLBKMT2ASLC6A2PRKCI | |
| Hydrochloric Acid SCHEMBL8435449 | 0.88 | POLB (0.44) | ALDH1A1POLBKMT2ASLC6A2PRKCI | |
| SCHEMBL8436327 | 0.87 | KMT2A (0.38) | ALDH1A1POLBKMT2ASLC6A2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8436071 | 0.86 | KMT2A (0.38) | ALDH1A1POLBKMT2ASLC6A2L3MBTL1 | |
| SCHEMBL8435363 | 0.81 | CHKA (0.36) | ALDH1A1KMT2ASLC6A2PRKCIL3MBTL1 | |
| SCHEMBL8056316 | 0.80 | SLC6A2 (0.38) | ALDH1A1SLC6A2HPGDMAPT | |
| Hydrochloric Acid SCHEMBL8039091 | 0.79 | ALDH1A1 (0.40) | ALDH1A1SLC6A2HPGDMAPT | |
| SCHEMBL8436069 | 0.78 | TRPM8 (0.35) | ALDH1A1SLC6A2USP2NPC1HPGD | |
| SCHEMBL8439461 | 0.78 | ALDH1A1 (0.34) | ALDH1A1SLC6A2L3MBTL1NPC1HSP90AA1 | |
| SCHEMBL8439945 | 0.76 | LMNA (0.34) | ALDH1A1KMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252581-A | Modulators of neurotransmitters | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | claimed |
| WO-2004082686-A2 | USE OF COMPOUNDS WITH COMBINED 5-HT1A AND SSRI ACTIVITIES TO TREAT SEXUAL DYSFUNCTION | DYNOGEN PHARMACEUTICALS, INC. (US) | 2004-09-30 | — | — | WO | disclosed |
| US-5856335-A | GLYCINE PARTIAL AGONISTS. | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-05 | — | — | US | disclosed |
| EP-0581106-B1 | Substituted aminothienopyridines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5519032-A | ANTIDEPRESSANTS, ANXIOLYTICS, ANTIEMETICS, ANTIPSYCHOTIC | HOECHST MARION ROUSSEL INC. (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0581106-A1 | Substituted aminothienopyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-02-02 | — | — | EP | disclosed |
| US-5252581-A | Modulators of neurotransmitters | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |