Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.63 |
| ▸ | DRD2 | P14416 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303876 | 0.88 | HTR1A (0.61) | HTR1ADRD2 | |
| SCHEMBL8303204 | 0.86 | HTR1A (0.69) | HTR1ADRD2 | |
| SCHEMBL8303559 | 0.85 | HTR1A (0.74) | HTR1ADRD2 | |
| SCHEMBL13533015 | 0.83 | HTR1A (0.81) | HTR1ADRD2 | |
| SCHEMBL21198039 | 0.78 | HTR1A (0.69) | HTR1ADRD2DRD4HTR2AHTR7 | |
| SCHEMBL8306494 | 0.78 | ALDH1A1 (0.52) | HTR1ADRD2ALDH1A1DRD4DRD3 | |
| SCHEMBL13533020 | 0.77 | HTR1A (1.00) | HTR1ADRD2DRD4HTR2AHTR7 | |
| SCHEMBL31051747 | 0.76 | ADRB1 (0.61) | HTR1A | |
| SCHEMBL31051832 | 0.76 | ADRB1 (0.61) | HTR1A | |
| SCHEMBL31052023 | 0.76 | ADRB1 (0.61) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | disclosed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | disclosed |