Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303927 | 0.80 | MEN1 (0.62) | CASP6MEN1KMT2AALDH1A1 | |
| SCHEMBL9313566 | 0.79 | PDK1 (0.52) | PDK1PDK2PDK3PDK4HCRTR1 | |
| SCHEMBL5647636 | 0.78 | PDK1 (0.57) | PDK1HCRTR1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18773990 | 0.78 | MEN1 (0.55) | PDK1PDK2PDK3PDK4HCRTR1 | |
| SCHEMBL9314705 | 0.76 | PDK1 (0.53) | PDK1PDK2PDK3PDK4HCRTR1 | |
| SCHEMBL9314017 | 0.76 | HCRTR1 (0.52) | PDK1PDK2PDK3PDK4HCRTR1 | |
| SCHEMBL15676788 | 0.76 | MEN1 (0.56) | PDK1PDK2PDK3PDK4HCRTR1 | |
| SCHEMBL9313991 | 0.75 | PDK1 (0.55) | PDK1HCRTR1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8302750 | 0.74 | CASP6 (0.48) | PDK1CASP6MEN1KMT2AALDH1A1 | |
| SCHEMBL9312693 | 0.74 | PDK1 (0.52) | PDK1HCRTR1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |