Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.56 |
| ▸ | HTR1B | P28222 | 10/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302847 | 0.80 | HTR1D (0.59) | HTR1DHTR1BHTR1AMAPT | |
| SCHEMBL28195627 | 0.79 | ALDH1A1 (0.60) | HTR1DHTR1BRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9050856 | 0.77 | HTR1D (0.50) | HTR1DHTR1BHTR1ASMN1; SMN2MAPT | |
| SCHEMBL5449763 | 0.74 | MEN1 (0.48) | SMN1; SMN2MEN1MAPTKMT2ALMNA | |
| SCHEMBL16494288 | 0.73 | RAB9A (0.71) | RAB9ASMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL8134911 | 0.73 | SLC2A1 (0.63) | HTR1DHTR1BHTR1ARAB9ASMN1; SMN2 | |
| SCHEMBL8302018 | 0.73 | HTR1D (0.82) | HTR1DHTR1BHTR1ARAB9ASMN1; SMN2 | |
| SCHEMBL8304123 | 0.71 | HTR1D (0.52) | HTR1DHTR1BHTR1AALDH1A1 | |
| SCHEMBL8132854 | 0.71 | HTR1D (1.00) | HTR1DHTR1BHTR1ASMN1; SMN2MEN1 | |
| SCHEMBL24157994 | 0.70 | RAB9A (1.00) | RAB9ASMN1; SMN2MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716650-B1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-24 | — | — | EP | claimed |
| EP-0716650-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-19 | — | — | EP | claimed |
| WO-1995006637-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-09 | — | — | WO | claimed |
| EP-0716650-B1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-24 | — | — | EP | disclosed |
| US-5696122-A | Indole and indoline derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-09 | — | — | US | disclosed |