Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.50 |
| ▸ | HTR1B | P28222 | 12/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302847 | 0.87 | HTR1D (0.59) | HTR1DHTR1BHTR1AMAPTMAPK1 | |
| SCHEMBL8306765 | 0.77 | HTR1D (0.56) | HTR1DHTR1BHTR1AMAPTSMN1; SMN2 | |
| SCHEMBL8304123 | 0.73 | HTR1D (0.52) | HTR1DHTR1BHTR1ATUBB4ATUBB | |
| SCHEMBL8127402 | 0.73 | HTR1D (0.61) | HTR1DHTR1BHTR1AMAPTHTR2A | |
| SCHEMBL8302018 | 0.69 | HTR1D (0.82) | HTR1DHTR1BHTR1AMAPTMAPK1 | |
| SCHEMBL28195627 | 0.67 | ALDH1A1 (0.60) | HTR1DHTR1BMAPTTUBB4ATUBB | |
| SCHEMBL8301915 | 0.66 | HTR1D (0.57) | HTR1DHTR1BHTR1AMAPTMAPK1 | |
| SCHEMBL8129693 | 0.66 | SLC2A1 (0.49) | HTR1DHTR1BHTR1AMAPT | |
| SCHEMBL9996874 | 0.66 | POLB (0.63) | MAPTMAPK1TP53SMN1; SMN2 | |
| SCHEMBL8132854 | 0.65 | HTR1D (1.00) | HTR1DHTR1BHTR1AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716650-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-19 | — | — | EP | claimed |
| WO-1995006637-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-09 | — | — | WO | claimed |