Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.40 |
| ▸ | ACE | P12821 | 8/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DUT | P33316 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994550 | 0.87 | MAPT (0.40) | MAPTTSHRACEACE2KMT2A | |
| SCHEMBL7291931 | 0.81 | MAPT (0.49) | MAPTTSHRACEACE2F2 | |
| SCHEMBL7265245 | 0.80 | MAPT (0.47) | MAPTTSHRPREPFAPF2 | |
| SCHEMBL9873842 | 0.77 | PREP (0.62) | MAPTSLC6A1ACEACE2PREP | |
| SCHEMBL9873839 | 0.77 | PREP (0.62) | MAPTSLC6A1ACEACE2PREP | |
| SCHEMBL769700 | 0.74 | MAPT (0.45) | MAPTTSHRF2KMT2A | |
| SCHEMBL8994595 | 0.73 | F2 (0.43) | MAPTTSHRACEACE2FAP | |
| SCHEMBL8304030 | 0.73 | ACE (0.36) | SLC6A1ACEACE2PREPFAP | |
| SCHEMBL7283530 | 0.73 | MEN1 (0.51) | SLC6A1ACEACE2KMT2A | |
| SCHEMBL7290889 | 0.72 | CHRM2 (0.43) | SLC6A1ACEACE2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537802-B1 | N-acylpyrrolidines, process for their preparation and their use for prevention and/or treatment of amnesia | ONO PHARMACEUTICAL CO (JP) | 1999-08-25 | — | — | EP | claimed |
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | claimed |
| EP-0537802-A2 | N-acylpyrrolidines and N-acylthiazolidines, process for their preparation and their use for prevention and/or treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-04-21 | — | — | EP | claimed |