Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ACE | P12821 | 8/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291931 | 0.87 | MAPT (0.49) | F2MAPTACEACE2TSHR | |
| SCHEMBL8994550 | 0.82 | MAPT (0.40) | MAPTACEACE2TSHRKMT2A | |
| SCHEMBL9871268 | 0.78 | PREP (0.56) | MAPTACEACE2KMT2AFAP | |
| SCHEMBL7265245 | 0.77 | MAPT (0.47) | F2MAPTTSHRKMT2AFAP | |
| SCHEMBL9446939 | 0.76 | PKM (0.52) | F2TSHRKMT2AALDH1A1CYP3A4 | |
| SCHEMBL9446944 | 0.74 | LMNA (0.48) | F2KMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL9178463 | 0.74 | ACE (0.43) | ACEACE2TSHRALDH1A1 | |
| SCHEMBL9182343 | 0.74 | CPT2 (0.51) | ACEACE2KMT2A | |
| SCHEMBL9257303 | 0.74 | MEN1 (0.52) | F2ACEACE2KMT2AMEN1 | |
| SCHEMBL7290318 | 0.74 | CPT2 (0.51) | ACEACE2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | disclosed |
| US-5411974-A | Thiazoline derivatives, treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-05-02 | — | — | US | disclosed |
| US-5401760-A | Thiazoline derivative for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |
| US-5212191-A | Thiazoline derivatives for treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |
| US-5053414-A | Thiazolidine derivatives, enzyme inhibitors; amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |