Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.55 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.55 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709679 | 0.92 | PRMT5 (0.64) | CHRM4PRMT5WDR77BRD4LMNA | |
| SCHEMBL9172873 | 0.88 | CHRM4 (0.47) | CHRM4PRMT5WDR77LMNASMN1; SMN2 | |
| SCHEMBL30711534 | 0.87 | CHRM4 (0.53) | CHRM4PRMT5LMNASMN1; SMN2HRH3 | |
| SCHEMBL30376364 | 0.87 | LMNA (0.49) | CHRM4PRMT5WDR77LMNASMN1; SMN2 | |
| SCHEMBL4969308 | 0.85 | LMNA (0.46) | CHRM4PRMT5WDR77SLC18A3BRD4 | |
| SCHEMBL28351668 | 0.84 | PRMT5 (0.60) | CHRM4PRMT5WDR77SLC18A3BRD4 | |
| SCHEMBL2278659 | 0.84 | TSHR (0.46) | CHRM4PRMT5WDR77BRD4LMNA | |
| SCHEMBL9174231 | 0.84 | HRH1 (0.51) | CHRM4LMNASMN1; SMN2POLBHRH3 | |
| SCHEMBL8306843 | 0.83 | HRH2 (0.46) | CHRM4PRMT5WDR77LMNASMN1; SMN2 | |
| SCHEMBL21159622 | 0.82 | BRD4 (0.61) | CHRM4SLC18A3BRD4LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663352-A | 4-phenyl-4-phenylpropyl(enyl)-piperidines as tachykinin antagonists | MERCK SHARP & DOHME LIMITED (GB) | 1997-09-02 | — | — | US | disclosed |
| EP-0711281-A1 | 4-PHENYL-4-PHENYLPROPYL(ENYL)-PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1996-05-15 | — | — | EP | disclosed |
| EP-0666856-A1 | 4-ARYLMETHYLOXYMETHYL PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1995-08-16 | — | — | EP | disclosed |
| WO-1995004042-A1 | 4-PHENYL-4-PHENYLPROPYL(ENYL)-PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |