Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 11/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.48 |
| ▸ | CCKBR | P32239 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309764 | 0.85 | CYP11B1 (0.61) | CYP11B1CYP11B2CYP19A1NR1I2ADORA3 | |
| SCHEMBL9669708 | 0.83 | CYP11B1 (0.67) | CYP11B1CYP11B2CYP19A1NR1I2ADORA3 | |
| SCHEMBL28067942 | 0.79 | CYP11B1 (0.69) | CYP11B1CYP11B2CYP19A1NR1I2ADORA3 | |
| SCHEMBL332630 | 0.78 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1NR1I2ADORA3 | |
| SCHEMBL25312529 | 0.78 | CYP11B1 (0.73) | CYP11B1CYP11B2CYP19A1NR1I2ADORA3 | |
| SCHEMBL7802979 | 0.78 | CYP11B1 (0.73) | CYP11B1CYP11B2CYP19A1NR1I2ADORA3 | |
| SCHEMBL27491722 | 0.78 | CYP11B1 (0.73) | CYP11B1CYP11B2CYP19A1NR1I2ADORA3 | |
| Hydrochloric Acid SCHEMBL9670895 | 0.77 | CYP11B1 (0.71) | CYP11B1CYP11B2CYP19A1NR1I2ADORA3 | |
| SCHEMBL2787690 | 0.75 | CYP19A1 (0.40) | CYP11B1CYP11B2CYP19A1MAPTMAOB | |
| Formaldehyde SCHEMBL27502810 | 0.74 | CYP11B1 (0.89) | CYP11B1CYP11B2CYP19A1NR1I2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |