Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309682 | 0.90 | TBXAS1 (0.60) | TBXAS1P2RX3CYP4F2CYP4A11 | |
| SCHEMBL8305260 | 0.87 | TBXAS1 (0.48) | TBXAS1P2RX3CYP4F2CYP4A11LMNA | |
| SCHEMBL8707244 | 0.86 | TBXAS1 (0.46) | TBXAS1P2RX3CYP4F2CYP4A11LMNA | |
| SCHEMBL8308660 | 0.84 | TBXAS1 (0.49) | TBXAS1CYP4F2CYP4A11CHRNA7 | |
| SCHEMBL10663180 | 0.83 | CYP4F2 (0.54) | TBXAS1P2RX3CYP4F2CYP4A11MAPT | |
| SCHEMBL8707246 | 0.82 | TBXAS1 (0.46) | TBXAS1P2RX3CYP4F2CYP4A11LMNA | |
| SCHEMBL8308674 | 0.81 | TBXAS1 (0.49) | TBXAS1P2RX3ALDH1A1RAB9A | |
| SCHEMBL8309271 | 0.80 | TBXAS1 (0.79) | TBXAS1LMNAALDH1A1TSHR | |
| SCHEMBL8308679 | 0.79 | CYP4F2 (0.41) | TBXAS1CYP4F2CYP4A11LMNACHRNA7 | |
| SCHEMBL8306671 | 0.78 | TBXAS1 (0.79) | TBXAS1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |