Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 17/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306671 | 0.92 | TBXAS1 (0.79) | TBXAS1TSHRTBXA2R | |
| SCHEMBL8309534 | 0.89 | TBXAS1 (1.00) | TBXAS1TBXA2RALDH1A1 | |
| SCHEMBL8308578 | 0.87 | TBXAS1 (0.77) | TBXAS1TSHR | |
| SCHEMBL8309013 | 0.84 | TBXAS1 (0.68) | TBXAS1TBXA2R | |
| SCHEMBL8309142 | 0.84 | TBXAS1 (0.70) | TBXAS1TSHRTBXA2RALDH1A1LMNA | |
| SCHEMBL8309682 | 0.83 | TBXAS1 (0.60) | TBXAS1 | |
| SCHEMBL8306769 | 0.82 | TBXAS1 (0.63) | TBXAS1TSHRALDH1A1LMNA | |
| SCHEMBL8304384 | 0.81 | TBXAS1 (1.00) | TBXAS1TBXA2R | |
| SCHEMBL8306012 | 0.81 | TBXAS1 (0.79) | TBXAS1TSHRTBXA2R | |
| SCHEMBL8307041 | 0.80 | TBXAS1 (0.49) | TBXAS1TSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |