Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305260 | 0.89 | TBXAS1 (0.48) | TBXAS1P2RX3RAB9AALDH1A1 | |
| SCHEMBL8307372 | 0.87 | TBXAS1 (0.53) | TBXAS1CYP3A4ALDH1A1 | |
| SCHEMBL8309682 | 0.82 | TBXAS1 (0.60) | TBXAS1P2RX3 | |
| SCHEMBL8307041 | 0.81 | TBXAS1 (0.49) | TBXAS1P2RX3RAB9AALDH1A1 | |
| SCHEMBL8309155 | 0.81 | CYP17A1 (0.47) | TBXAS1CYP3A4NAMPTCA1CA2 | |
| SCHEMBL8309271 | 0.79 | TBXAS1 (0.79) | TBXAS1ALDH1A1 | |
| SCHEMBL4495406 | 0.78 | CYP4F2 (0.56) | IDO1NAMPTCA1CA2RAB9A | |
| SCHEMBL8707244 | 0.78 | TBXAS1 (0.46) | TBXAS1P2RX3RAB9AKMT2A | |
| SCHEMBL8306671 | 0.77 | TBXAS1 (0.79) | TBXAS1 | |
| SCHEMBL10663180 | 0.76 | CYP4F2 (0.54) | TBXAS1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |