Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.62 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17526169 | 0.89 | KEAP1 (0.56) | CRHBPCRHR2KEAP1HTR6ERBB2 | |
| SCHEMBL11027219 | 0.85 | ERBB2 (0.71) | CRHBPCRHR2ERBB2HSP90AA1HSP90AB1 | |
| SCHEMBL3382327 | 0.84 | MAPT (0.63) | KEAP1KMT2AALDH1A1GAAHTT | |
| SCHEMBL3781935 | 0.83 | CRHBP (0.62) | CRHBPCRHR2KEAP1HTR6ERBB2 | |
| SCHEMBL4050412 | 0.82 | ERBB2 (0.68) | CRHBPCRHR2KEAP1HTR6ERBB2 | |
| SCHEMBL22315132 | 0.82 | MEN1 (0.67) | CRHBPCRHR2KEAP1ERBB2HSP90AA1 | |
| SCHEMBL2073110 | 0.82 | CRHBP (0.61) | CRHBPCRHR2ERBB2HSP90AA1HSP90AB1 | |
| SCHEMBL7170804 | 0.82 | ERBB2 (0.63) | CRHBPCRHR2ERBB2HSP90AA1HSP90AB1 | |
| SCHEMBL18161437 | 0.82 | KEAP1 (0.56) | KEAP1HTR6KMT2AALDH1A1GAA | |
| SCHEMBL1970942 | 0.81 | KMT2A (0.71) | CRHBPCRHR2KEAP1HTR6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |