Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.74 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.74 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.74 |
| ▸ | TBXAS1 | P24557 | 11/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL771716 | 0.86 | CYP11B1 (1.00) | CYP11B1CYP19A1CYP11B2TBXAS1CYP1A2 | |
| Hydrochloric Acid SCHEMBL8307735 | 0.85 | CYP11B1 (0.97) | CYP11B1CYP19A1CYP11B2TBXAS1CYP1A2 | |
| Benzylimidazole SCHEMBL3139033 | 0.84 | TBXAS1 (0.73) | CYP11B1CYP19A1CYP11B2TBXAS1CYP1A2 | |
| Hydrazine SCHEMBL28019549 | 0.83 | CYP11B1 (0.94) | CYP11B1CYP19A1CYP11B2TBXAS1CYP1A2 | |
| Benzonitrile SCHEMBL8142529 | 0.74 | CYP19A1 (0.46) | CYP11B1CYP19A1CYP11B2TBXAS1 | |
| SCHEMBL11477599 | 0.74 | TBXAS1 (1.00) | CYP11B1CYP19A1CYP11B2TBXAS1CYP1A2 | |
| SCHEMBL1024261 | 0.73 | CYP11B1 (0.84) | CYP11B1CYP19A1CYP11B2TBXAS1CYP1A2 | |
| SCHEMBL29239316 | 0.73 | TBXAS1 (0.72) | CYP11B1CYP19A1CYP11B2TBXAS1CYP1A2 | |
| SCHEMBL4492287 | 0.73 | CYP19A1 (0.75) | CYP11B1CYP19A1CYP11B2TBXAS1CYP1A2 | |
| SCHEMBL5224791 | 0.73 | CYP19A1 (0.58) | CYP11B1CYP19A1CYP11B2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |