Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507823 | 0.74 | CYP19A1 (0.54) | CYP11B1CYP11B2CYP19A1HDAC8HDAC6 | |
| SCHEMBL9164995 | 0.74 | KIF11 (0.51) | CYP11B1CYP11B2CYP19A1HDAC8HDAC6 | |
| SCHEMBL28714480 | 0.74 | RAB9A (0.47) | HSP90AA1HSP90B1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL28327501 | 0.72 | F2 (0.46) | CYP11B1CYP11B2HDAC6KDM4EPOLB | |
| SCHEMBL1507984 | 0.72 | HDAC8 (0.49) | HSP90AA1HSP90B1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL1507767 | 0.72 | CYP19A1 (0.51) | HSP90AA1HSP90B1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL28710568 | 0.71 | MAPT (0.51) | HSP90AA1HSP90B1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL11534586 | 0.71 | LMNA (0.49) | HSP90AA1HSP90B1ALKBH1SMN1; SMN2CYP3A4 | |
| SCHEMBL1507797 | 0.70 | BRD4 (0.51) | CYP11B1CYP11B2CYP19A1HDAC8HDAC6 | |
| SCHEMBL7855826 | 0.70 | LMNA (0.59) | HSP90AA1HSP90B1CYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |