Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307774 | 0.78 | GABRA1 (0.49) | TP53L3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL10655256 | 0.73 | ALDH1A1 (0.73) | ALDH1A1LMNAMAPTRAB9ANPSR1 | |
| SCHEMBL18473735 | 0.68 | MAPK10 (0.46) | TP53L3MBTL1ALDH1A1LMNARAB9A | |
| SCHEMBL1416929 | 0.67 | MAPT (0.52) | TP53L3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL3675035 | 0.67 | ALDH1A1 (0.54) | ALDH1A1LMNAMAPTRAB9ANPSR1 | |
| SCHEMBL9447417 | 0.66 | ALDH1A1 (0.47) | ALDH1A1LMNAMAPTRAB9ANPSR1 | |
| SCHEMBL11558620 | 0.66 | CES2 (0.54) | ALDH1A1LMNAMAPTRAB9ANPSR1 | |
| SCHEMBL18964943 | 0.66 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPTRAB9AMAPK1 | |
| SCHEMBL9447416 | 0.66 | ALDH1A1 (0.47) | ALDH1A1LMNAMAPTRAB9ANPSR1 | |
| SCHEMBL11339856 | 0.66 | CES2 (0.54) | ALDH1A1LMNAMAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922741-A | 5-aminopyrazoles useful as tyrosine kinase inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0906286-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997040019-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-30 | — | — | WO | disclosed |