Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 14/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309155 | 0.88 | CYP17A1 (0.47) | TBXAS1CYP3A4 | |
| SCHEMBL8308674 | 0.87 | TBXAS1 (0.49) | TBXAS1CYP3A4ALDH1A1 | |
| SCHEMBL8304942 | 0.85 | TBXAS1 (0.54) | TBXAS1 | |
| SCHEMBL8305362 | 0.83 | TBXAS1 (0.76) | TBXAS1 | |
| SCHEMBL8310008 | 0.83 | TBXAS1 (0.52) | TBXAS1 | |
| SCHEMBL8592476 | 0.82 | HPGD (0.42) | — | |
| SCHEMBL8309224 | 0.82 | CYP3A4 (0.48) | TBXAS1CYP3A4 | |
| SCHEMBL8309268 | 0.82 | TBXAS1 (0.79) | TBXAS1 | |
| SCHEMBL8307393 | 0.81 | TBXAS1 (0.62) | TBXAS1 | |
| SCHEMBL8310249 | 0.81 | TBXAS1 (0.62) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0579618-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | Pfizer Limited (GB) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992017451-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LIMITED (GB) | 1992-10-15 | — | — | WO | disclosed |