Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307372 | 0.88 | TBXAS1 (0.53) | TBXAS1CYP3A4 | |
| SCHEMBL8592476 | 0.88 | HPGD (0.42) | CA1CA2CYP4F2CYP4A11NAMPT | |
| SCHEMBL4495406 | 0.83 | CYP4F2 (0.56) | CA1CA2CYP4F2CYP4A11NAMPT | |
| SCHEMBL8304916 | 0.83 | PDE3B (0.36) | CA1CA2CYP4F2CYP4A11GLA | |
| SCHEMBL8308674 | 0.81 | TBXAS1 (0.49) | TBXAS1CA1CA2CYP3A4NAMPT | |
| SCHEMBL8304913 | 0.80 | TBXAS1 (0.45) | CYP17A1TBXAS1CYP3A4NAMPT | |
| SCHEMBL8310260 | 0.80 | TBXAS1 (0.50) | TBXAS1CYP4F2CYP4A11NAMPTMAPT | |
| SCHEMBL2024124 | 0.79 | CYP17A1 (0.53) | CYP17A1CA1CA2CYP3A4NAMPT | |
| SCHEMBL8308006 | 0.79 | CYP4F2 (0.47) | TBXAS1CA1CA2CYP4F2CYP4A11 | |
| SCHEMBL8307474 | 0.77 | TBXAS1 (0.58) | TBXAS1CYP4F2CYP4A11NAMPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |