Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 8/20 | 0.70 |
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALPG | P10696 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.49 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.49 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607910 | 0.88 | PDE7A (0.78) | PDE7ALMNAALDH1A1MAPTPDE4B | |
| SCHEMBL27581742 | 0.86 | PDE7A (0.75) | PDE7ALMNAALDH1A1MAPTPDE4B | |
| SCHEMBL7607268 | 0.85 | PDE7A (0.58) | PDE7ALMNAALDH1A1MAPTPDE4B | |
| SCHEMBL27581790 | 0.85 | PDE7A (0.58) | PDE7ALMNAALDH1A1MAPTPDE4B | |
| SCHEMBL13240464 | 0.81 | LMNA (0.73) | PDE7ALMNAALDH1A1MAPTPDE4B | |
| SCHEMBL8308859 | 0.80 | PDE7A (1.00) | PDE7ALMNAALDH1A1MAPTPDE4B | |
| SCHEMBL27581731 | 0.80 | PDE7A (0.67) | PDE7ALMNAALDH1A1MAPTPDE4B | |
| SCHEMBL8308443 | 0.80 | PDE7A (0.63) | PDE7ALMNAALDH1A1MAPTPDE4B | |
| SCHEMBL7605579 | 0.80 | PDE7A (0.67) | PDE7ALMNAALDH1A1MAPTPDE4B | |
| SCHEMBL7263676 | 0.79 | ALDH1A1 (0.64) | PDE7ALMNAALDH1A1MAPTPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |